Trial

FIGARO-DKD

(N = 7437)

FIDELIO

(N = 5734)

CREEDENCE

(N = 4401)

DAPA-CKD

(N = 4304)

IDNT

(N = 1715)

P VALUE

Year Published

2021

2020

2019

2020

2001

DM%

100

100

100

67

100

<0.00001

Mean eGFR (ml/min) or Cr (mg/dL)

68

44

56

43

1.67

0.009

GFR range (mL/min)

25 - 90

25 - 60

30 - 90

25 - 75

N/A

Proteinuria (g/d)

0.31

0.83

0.92

0.95

2.9

0.028

HbA1c

7.7

7.7

8.3

N/A

8.1

Age

64

65

63

62

59

<0.00001

M/F

69/31

69/31

66/34

67/33

67/33

W/B/A

72/3.5/20

63/5/25

67/5/20

52/5/35

76/11/4

ACE/ARB

100

100

100

100

50

SGLT2 USE (%)

8

4.6

100

100

0

Renal Outcome RR (%)

13

18

30

39

20

<0.0001

Trial length (mos)

41

30

30

28

30

<0.00001