Trial medicine intake

Timeline

0 h

1 h

3 h

3.5 h

4 h

Baseline

Trial medicine treatment

Supine BP during renography

After renography

Changes between baseline and supine BP

Systolic

(mmHg)

bBP

- tolvaptan

137 ± 12

138 ± 12

135 ± 13*

140 ± 16

2 ± 10

- placebo

138 ± 18

141 ± 16

141 ± 18

144 ± 21

−3 ± 15

cBP

- tolvaptan

126 ± 11

127 ± 9

125 ± 13

131 ± 14

2 ± 11

- placebo

128 ± 16

130 ± 15

131 ± 19

134 ± 21

−3 ± 15

Diastolic

(mmHg)

bBP

- tolvaptan

92 ± 9

94 ± 9

87 ± 10

96 ± 11

5 ± 6

- placebo

92 ± 10

95 ± 12

89 ± 14

96 ± 16

4 ± 8

cBP

- tolvaptan

93 ± 9

95 ± 9

88 ± 10

98 ± 11

5 ± 7

- placebo

93 ± 10

97 ± 12

90 ± 13

98 ± 15

5 ± 8