Parameters

Current study (2015-2019)

N = 11,377

Kafando et al. [9] , (2000-2004)

N = 2341

Simporé et al. [6] , (1997-2000)

N = 28,226

Incidence of hemoglobinopathies: Incidence; [95% CI]; (cumulative incidence)

Total SCD

1.90; [1.65 - 2.16]; (1:53)

1.75; [1.26 - 2.37]; (1:57)

1.36; [1.23 - 1.50]; (1:73)^a

SS

0.53; [0.40 - 0.68]; (1:189)

0.60; [0.33 - 1.00]; (1:167)

0.20; [0.15 - 0.26]; (1:487)^a

SC

1.37; [1.16 - 1.60]; (1:73)

1.15; [0.76 - 1.67]; (1:87)

1.16; [1.04 - 1.29]; (1:86)

AS

7.95; [7.45 - 8.46]; (1:12)

7.30; [6.28 - 8.43]; (1:14)

8.09; [7.77 - 8.41]; (1:12)

AC

16.33; [15.65 - 17.02]; (1:6)

16.87; [15.38 - 18.45]; (1:6)

19.17; [18.71 - 19.63]; (1:5)^a

CC

1.05; [0.87 - 1.25]; (1:95)

1.37; [0.94 - 1.92]; (1:73)

1.43; [1.29 - 1.58]; (1:70)^a

Incidence of abnormal Hb S and C: Incidence; [95% CI]; (cumulative incidence)

HbS

9.75; [9.20 - 10.31]; (1:10)

9.05; [7.92 - 10.29]; (1:11)

9.45; [9.11 - 9.79]; (1:10)

HbC

18.65; [17.93 - 19.38]; (1:5)

19.35; [17.77 - 21.01]; (1:5)

21.76; [21.28 - 22.25]; (1:4)^a

Allelic frequencies of β-globin gene alleles: Relative frequency; [95% CI]

β

0.850; [0.843 - 0.856]

0.848; [0.833 - 0.862]

0.836; [0.832 - 0.840]^a

β^S

0.051; [0.047 - 0.055]

0.048; [0.039 - 0.057]

0.048; [0.045 - 0.050]

β^C

0.099; [0.093 - 0.105]

0.104; [0.092 - 0.117]

0.116; [0.112 - 0.120]^a