S.No. | Site (activation of hypothalamus) | Effect |
1 | Inflammatory pathway | Insulin resistance and leptin resistance |
2 | Melanocortin 4 receptor (MC4R) resistance | Neuronal circulatory downstream of ARC |
3 | Leptin resistance | Anorectic action blunted and lowers gluconeogenesis |
4 | HGP (hepatic glucose production) | Hypothalamic sensing of nutrients blunted |