V1

3.58

V2

13.0 + 0.49 × (Age—64)

V3

186

Clearances (L/min)

CL1

0.77 + (WT—54) × 0.04 + (HT—158) × 0.03

CL2

0.89 + 0.12 × (Age—64)

CL3

0.98 × exp ((Age—64)/10)