Vigneault et al. [24]

Meta-analysis of 29 papers

7 cardiac, 3 gynecology, 1 thoracic, 2 urology, 1 otorhinolaryngology, 14 abdominal surgery, 1 orthopedic surgery


IV lidocaine bolus prior to infusion (infusion rate ≤ 3 mg/kg/h)

IV Lidocaine infusion reduced post-operative pain during rest and during movement. It also reduced opioid requirement, nausea, vomiting, time to first flatus, time to first feces and length of hospital stay abdominal surgery was strongly associated with these outcomes.

Wuethrich et al. [25]


Laparoscopic renal surgery


IV lidocaine 1.5 mg/kg/hr bolus during induction followed by intraoperative infusion of 2 and 1.3 mg/kg/h for 24 h post operatively

Lidocaine did not influence the length of the hospital stay readiness for discharge opioid consumption, return of bowel function or inflammatory and stress responses after laparoscopic renal surgery.

Wongyinsinn et al. [26]


Laparoscopic colorectal surgery


IV lidocaine 1 mg/kg/h + PCA (patient controlled analgesia) morphine for the first 48 h after surgery

Both IV lidocaine and thoracic epidural analgesia (TEA) had similar impact on restoration of bowel function; however, TEA provided better analgesia in patients undergoing rectal surgery. Time out of bed dietary intake and hospital stay were similar.