Reference

Type of study

Type of surgery

Sample size

Lidocaine IV infusion

Outcome

Farag et al. [7]

RCT

Complex spine surgery

116

IV lidocaine 2 mg/kg/h with maximum of 200 mg/h during induction of anesthesia and continued until discharge from post anesthesia care unit for maximum of 8 hours

IV lidocaine significantly improved post-operative pain after complex spine surgery however, post-operative nausea and vomiting and the during of hospitalization did not differ significantly.

Insler et al. [16]

RCT

CABG

(Coronary Artery Bypass Surgery)

100

IV lidocaine 1.5 mg/kg bolus followed by 30 µg/kg/min during surgery 48 hours post operatively

Low dose lidocaine did not significantly reduce post-operative pain. Also, it had no impact on time of extubation, ICU stay or hospital length of stay.

Kang et al. [17]

RCT

Subtotal gastrectomy

48

IV lidocaine 1.5 mg/kg bolus 20 minutes before incision followed by a continuous infusion of 1.5 mg/kg/h until the end of surgery

Intraoperative lidocaine decreased opioid consumption and length of hospital stay after gastrectomy. No differences were noted between the groups in pain intensity or duration of ileus.

Kyoung-Tae et al. [18]

RCT

Lumbar microdiscectomy

51

IV lidocaine 1.5 mg/kg bolus followed by a 2 mg/kg/h infusion until the end of surgery

Lidocaine decreased pain perception and hence, also the consumption of opioid and the severity of postoperative pain that further contributed to shortening of hospital stay.

Kim et al. [19]

RCT

Laparoscopic appendectomy

68

IV lidocaine 1.5 mg/kg bolus followed by a continuous infusion of 2 mg/kg/h throughout surgery

Lidocaine reduces pain and fentanyl consumption. The shoulder tip pain and post-operative nausea and vomiting were also reduced.

Lauwick et al. [20]

RCT

Laparoscopic prostatectomy

40

IV lidocaine 2 mg/kg/h during surgery, 1 mg/kg/min for the first 24 hrs after surgery

Lidocaine infusion attenuated the deterioration in functional walking capacity and hand an opioid sparing effect.

Martin et al. [21]

RCT

Total Hip arthroplasty

60

IV lidocaine 1.5 mg/kg 30 min before surgical incision followed by continuous infusion of 1.5 mg/kg/h. The infusion ended 60 min after skin closure

The study didn’t show any benefit of perioperative administration of low dose IV lidocaine in terms of post-operative analgesia and functional recovery after total hip arthroplasty.

Oliveira et al. [22]

RCT

Laparoscopic

bariatric surgery

50

IV lidocaine 1.5 mg/kg bolus + 2 mg/kg/h till the end of surgical procedure

Systemic lidocaine reduced opioids (morphine) consumption and thereby, improving the quality of post-operative recovery.

Peng et al. [8]

RCT

Supratentorial tumor surgery

94

IV lidocaine 1.5 mg/kg bolus followed by continuous infusion of 2 mg/kg/h until the end of surgery

Systemic lidocaine profoundly reduced the proportion of patients with acute pain after surgery.

Striebel et al. [23]

RCT

Elective tonsillectomy (1992)

40

IV lidocaine 1.5 mg/kg 30 min before the surgery followed by 2 mg/kg/h over 6 hr and 0.5 mg/kg/h for another 18 h

Intravenous lidocaine did not significantly reduce postoperative pain after tonsillectomy in the dosage used.