| Cata JP (2016) [12] | Retrospective study of 792 non-metastatic breast cancer to evaluate if use of PVB prolongs their survival | Mastectomy | 198 given PVB, remainder treated with opioid based analgesia | Significantly lower intraoperative fentanyl consumption No significant change in recurrence-free survival | - |
| Hards M (2016) [13] | Retrospective study of 27 breast cancer patients | Mastectomy | 16 had serratus block; 11 had wound infiltration | No patients with SPB had severe pain in recovery or POD 1 2 patients who had wound infiltration had severe pain in recovery, and 3 patients on POD1 | - |
| Bonomi S (2016) [14] | Breast cancer patients | Implant-based breast reconstructions | Bilateral Pecs block, with GA | Eliminated need for post-operative opoid no PONV lower mean VAS score throughout inpatient stay | - |
| Fallatah S (2016) [15] | 40 patients with unilateral breast cancer | Unilateral lumpectomy and axillary lymph nodes dissection | 20 patients received peroperative unilateral PVB from T2-6; 20 patients received postoperative PCA morphine; both with GA | Significantly lower pain scores, shorter hospital stay, higher satisfaction score, and less PONV in patients who had PVB | 2 patients who had PVB had inadvertent vascular puncture and one with pain at the site of injection that continued beyond a month |
| Wolf O (2016) [16] | RCT involving 74 breast cancer patients | Prosthetic breast reconstruction | PVB with GA or GA alone | Significantly less intraoperative and postoperative opioid consumption Less antiemetic medication | - |
| Khemka R (2016) [17] | 2 patients with unilateral breast malignancy | breast conservation surgery with dissection of the axillary nodes followed by reconstruction using a LD pedicle flap | Pecs I block and serratus anterior plane block with GA | No intraoperative opioid. 1 had 6 mg morphine 0 - 48 hs. The other had 4 mg of morphine 0 - 48 hs | - |
| Fusco P (2016) [18] | 78 year old severe respiratory insufficiency for pulmonary fibrosis | Radical mastectomy and axillary dissection | Serratus plane block, PECS I block, parasternal LA injections | Complete anaesthesia of mammary and axillary regions. No opioids first 24 hs of surgery | - |