Healthy controls

N = 30

No HE

N = 17

MHE

N = 13

Overt HE

N = 25

P value

No HE versus healthy controls

Overt versus

No HE

Overt versus

MHE

Bilirubin (mg/dl)

0.62 ± 0.23

1.36 ± 0.59

1.88 ± 1.52

5.87 ± 9.10

0.000^***

0.049^*

0.127

Albumin (g/dl)

4.03 ± 0.93

2.79 ± 0.67

2.39 ± 0.70

1.87 ± 0.46

0.000^***

0.000^***

0.008^**

Prothrombin time (sec)

11.21 ± 1.9

15.33 ± 1.90

16.28 ± 2.31

20.44 ± 6.07

0.000^***

0.002^**

0.023^*

INR

1.01 ± 0.09

1.35 ± 0.16

1.39 ± 0.18

1.71 ± 0.51

0.000^***

0.008^**

0.041^*

Child Pugh score

5

6.76 ± 1.56

7.85 ± 1.95

12.04 ± 2.17

0.000^***

0.000^***

0.000^***