| Absorption | Distribution | Metabolism | Toxicity | ||||||||||||
| Molecules | HIA | Caco-2 | MDCK | PPB | BBB | CYP2C19 Inhibition | CYP2C9 Inhibition | CYP2D6 Inhibition | CYP2D6 Substrat | CYP3A4 Inhibition | CYP3A4 Substrat | hERG Inhibition | Cancérogénicité | Mutagénicité | |
| Mouse | Rat | (AMES-Test) | |||||||||||||
| TH1 | 80.314 | 0.954 | 0.065 | 100.000 | 0.059 | No | Inhibition | No | No | Inhibition | No | Ambiguous | negative | negative | Mutagen |
| TH2 | 78.105 | 3.942 | 0.129 | 83.349 | 0.110 | No | No | No | No | No | Substrate | Weak | negative | negative | Mutagen |
| TH3 | 81.331 | 5.884 | 0.048 | 84.334 | 0.157 | No | No | No | No | No | Substrate | Risk | negative | negative | Mutagen |
| TH4 | 97.856 | 19.830 | 37.217 | 93.969 | 0.029 | No | No | No | No | No | Weak | Weak | negative | negative | Mutagen |
| TH5 | 96.479 | 24.365 | 0.237 | 77.440 | 0.022 | No | No | No | No | No | Substrate | Risk | negative | negative | Mutagen |
| TH6 | 92.604 | 9.640 | 0.058 | 61.973 | 0.017 | No | No | No | No | No | Substrate | AVERAGE | negative | Positive | Mutagen |
| TH7 | 95.681 | 22.157 | 0.251 | 75.553 | 0.019 | No | No | No | No | No | Substrate | Risk | negative | Positive | Mutagen |
| TH9 | 75.262 | 2.251 | 1.457 | 84.178 | 0.046 | No | No | No | No | No | No | AVERAGE | Positive | negative | Mutagen |
| TH10 | 27.749 | 0.391 | 4.519 | 82.465 | 0.027 | No | No | No | No | No | No | Risk | negative | negative | Mutagen |
| TH11 | 90.746 | 2.880 | 0.448 | 59.640 | 0.017 | No | No | No | No | No | Substrate | Medium Risk | negative | negative | Mutagen |
| TH12 | 97.561 | 57.095 | 24.302 | 91.127 | 0.095 | No | No | Yes | Yes | Yes | Weak | Medium Risk | negative | Positive | Mutagen |
| TH13 | 95.282 | 2.441 | 11.789 | 89.656 | 0.023 | No | No | No | No | No | No | Medium Risk | negative | negative | Mutagen |
| TH14 | 97.866 | 16.659 | 53.574 | 92.374 | 0.025 | No | No | No | No | No | No | Low Risk | negative | negative | Mutagen |