| I. BL | II. 3 M | III. 6 M | IV. 9 M | V. 12 M | VI. 15 M | VII. 18 M | ANOVA |
Group A (n = 24) | 4.6 ± 2.9 | 4.4 ± 3.6 | 4.8 ± 4.0- | 4.4 ± 3.3 | 4.4 ± 2.8 | 3.5 ± 2.5 | 2.8 ± 2.1 | I > VII* |
Placebo A (n = 22) | 4.3 ± 2.4 | 6.1 ± 4.6 | 6.5 ± 4.4 | 6.6 ± 4.1 | 6.0 ± 3.7 | 7.3 ± 3.9 | 6.9 ± 3.7 | _ |
Group B (n = 32) | 4.0 ± 3.6 | 3.5 ± 2.6 | 2.9 ± 2.7 | 2.8 ± 2.5 | 2.7 ± 2.9 | 2.1 ± 1.8 | 1.9 ± 1.7 | I > VI* I > VII* |
Placebo B (n = 20) | 4.1 ± 2.5 | 6.0 ± 4.6 | 6.3 ± 4.4 | 6.4 ± 4.3 | 5.8 ± 3.8 | 7.0 ± 4.1 | 6.9 ± 3.8 | I < VI* |