I. BL

II. 3 M

III. 6 M

IV. 9 M

V. 12 M

VI. 15 M

VII. 18 M

ANOVA

Group A (n = 24)

4.6 ± 2.9

4.4 ± 3.6

4.8 ± 4.0-

4.4 ± 3.3

4.4 ± 2.8

3.5 ± 2.5

2.8 ± 2.1

I > VII*

Placebo A (n = 22)

4.3 ± 2.4

6.1 ± 4.6

6.5 ± 4.4

6.6 ± 4.1

6.0 ± 3.7

7.3 ± 3.9

6.9 ± 3.7

_

Group B (n = 32)

4.0 ± 3.6

3.5 ± 2.6

2.9 ± 2.7

2.8 ± 2.5

2.7 ± 2.9

2.1 ± 1.8

1.9 ± 1.7

I > VI*

I > VII*

Placebo B (n = 20)

4.1 ± 2.5

6.0 ± 4.6

6.3 ± 4.4

6.4 ± 4.3

5.8 ± 3.8

7.0 ± 4.1

6.9 ± 3.8

I < VI*