I. BL

II. 3 M

III. 6 M

IV. 9 M

V. 12 M

VI. 15 M

VII. 18 M

ANOVA

Group A (n = 24)

19.9 ± 2.5

20.2 ± 2.8

21.0 ± 3.5

21.7 ± 3.2

21.9 ± 3.0

22.1 ± 3.5

22.9 ± 3.2

I < V*

I < VI*

I < VII*

Placebo A (n = 22)

18.2 ± 4.3

17.2 ± 4.5

17.7 ± 4.7

17.5 ± 4.8

17.2 ± 5.4

16.0 ± 5.3

16.0 ± 5.0

_

Group B (n = 32)

19.9 ± 5.9

21.3 ± 4.9

21.3 ± 4.7

21.1 ± 5.2

21.7 ± 4.5

22.2 ± 4.8

22.3 ± 5.0

_

Placebo B (n = 20)

18.7 ± 4.3

17.6 ± 4.7

18.0 ± 4.8

18.0 ± 4.8

17.4 ± 4.3

16.5 ± 4.9

15.4 ± 4.2

I > VII*