I. BL

II. 3 M

III. 6 M

IV. 9 M

V. 12 M

VI. 15 M

VII. 18 M

ANOVA

Group A (n = 24)

25.5 ± 3.3

26.5 ± 3.2

26.6 ± 3.1

26.6 ± 3.1

26.9 ± 3.2

26.8 ± 2.9

27.1 ± 2.7

I < VII*

Placebo A (n = 22)

23.5 ± 3.6

23.7 ± 3.8

23.0 ± 3.7

24.0 ± 3.6

22.8 ± 3.6

22.4 ± 4.1

22.1 ± 4.1

_

Group B (n = 32)

26.3 ± 2.3

26.9 ± 2.1

27.4 ± 1.8

27.7 ± 2.0

27.6 ± 2.1

27.7 ± 1.9

28.0 ± 1.7

I < IV*

I < V*

I < VI*

I < VII*

Placebo B (n = 20)

23.8 ± 3.5

23.3 ± 3.7

22.7 ± 3.7

23.0 ± 3.3

22.0 ± 3.1

21.4 ± 3.7

20.3 ± 3.8

I > VI*

I > VII*