Trial*

Components of risk of bias/key risk criteria

Summary within trial

Comments on high risk components―(explain briefly why)

1

2

3

4

5

6

Ando et al. (2018)

H

H

H

H

L

H

H = 5

L = 1

U = 0

Selection bias: No identification of sequent generation or allocation concealment.

Detection/Performance bias: No blinding of assessors mentioned.

Other bias: No protocol. Choice of statistics questionable.

Crogan et al. (2008)

H

H

H

H

L

H

H = 5

L = 1

U = 0

Selection bias: No identification of sequent generation or allocation concealment.

Detection/Performance bias: No blinding of assessors mentioned.

Other bias: No protocol. Choice of statistics questionable.

Garcia-Schinzari et al. (2014)

H

H

H

H

L

H

H = 5

L = 1

U = 0

Selection bias: No identification of sequent generation or allocation concealment.

Detection/Performance bias: No blinding of assessors mentioned.

Other bias: No protocol. Choice of statistics questionable. Sample size not justified

Falzon et al. (2015)

L

L

L

L

L

H

H = 1

L = 5

Other bias: No protocol.

Heiney et al. (2012)

H

H

L

L

L

H

H = 3

L = 3

Selection bias: No identification of sequent generation or allocation concealment.

Other bias: No protocol. Sample size not considered.

Heiney et al. (2013)

H

H

L

L

L

H

H = 3

L = 3

Selection bias: No identification of sequent generation or allocation concealment.

Other bias: No protocol. Sample size not considered. Refers to Heiney et al. (2012) for procedures and methods.

Heiney et al. (2015)

H

H

L

L

L

H

H = 3

L = 3

Selection bias: No identification of sequent generation or allocation concealment.

Other bias: No protocol. Sample size not considered. Refers to Heiney et al. (2012) for procedures and methods.

Song et al. (2012)

H

H

H

H

L

H

H = 5

L = 1

U = 0

Selection bias: No identification of sequent generation or allocation concealment.

Detection/Performance bias: No blinding of assessors mentioned.

Other bias: No protocol. Choice of statistics questionable.