| Degree of Skin Toxicity | Grade 0 absent | Grade 1 mild | Grade 2 moderate | Grade 3 severe | Grade 4 very severe |
1 | Pain in the area where papules and/or pustules emerge (skin rash) | 0 | 1 | 2 | 3 | 4 |
2 | Pruritus in the area where papules and/or pustules emerge (skin rash) | 0 | 1 | 2 | 3 | 4 |
3 | Pain in the area where skin is dry (xerosis) | 0 | 1 | 2 | 3 | 4 |
4 | Pruritus in the area where skin is dry (xerosis) | 0 | 1 | 2 | 3 | 4 |
5 | Pain in the disruption part around the nail (paronychia) | 0 | 1 | 2 | 3 | 4 |