Weiss, Santander, Torres, 2013 [16]

Longitudinal study

n = 1

- 22 year old woman who has had depression, catatonia, and Cotard’s syndrome; has neuroleptic malignant syndrome as result of using Risperidone, recovered later; has leukoencephalopathy

4 months

Brain NMR

ECT

Haloperidol

Lorazepam

Risperidone

Chlorpromazine

Zolpidem

Life support in ICU

Bromocriptine

Nasogastric intubation

Olanzapine

Lamotrigine

Trouble sleeping

Decreased attention span

Depressive episode

Restlessness

Delusions, claimed that she killed her mother, the world, saved the world, etc.

Catatonia (motor rigidity)

After maintenance of ECT for 2 months, with lamotrigine and olanzapine, (4 months), she improved greatly and no longer showed delusional and psychotic symptoms. She has been euthymic and functional

The patient experienced neurological damage (leukoencephalopathy), and had an episode of neurological malignant syndrome as result of one of her prior treatments, which may have caused some of the results and cannot compare to other case studies of Cotard’s syndrome

It is a case study, so it cannot be generalized

United States