| Grover, Shah, Ghosh, 2010 [14] | Longitudinal study | n = 1
- 37 year old woman who claimed lycanthropy (converting into a pig), no history of illness, stressors possibly induced the cotard’s syndrome, lives in urban area | 6 weeks (1.5 months) | Venlaflaxine ECT Olanzapine International Statistical Classification of Diseases, 10th Revision hemogram, renal function tests, liver function tests, electrocardiogram, chest x-ray posterior-anterior view Modified bilateral ECT Atropine thiopental sodium Succinylcholine EEG Hamilton depression rating scale | Claimed lycanthropy (that her bones were converting to pig bones and treat she and her children overall were turning into pigs) Claimed God was punishing her for skipping prayers and religious pilgrimages Decreased sleep Anxiety Depressed mood Cried frequently Hopelessness Insomnia Poor appetite Guilt | Was treated with a combination of venlaflaxine, olanzapine, and ECT, given 6 sessions of ECT, all of her depressive, sad, and delusional and/or psychotic symptoms resolved
Her depression rating scale based on the Hamilton Depression Rating Scale decreased from 30 to 3 by discharge | Case study, meaning the results can’t be generalized
A lot of her symptoms of guilt and depression relate to her religion and belief of herself being punished by God
Many symptoms also relate to the fact that she had a suspected malignant tumor and complications
Lycanthropy is a very specific symptom associated with Cotard’s syndrome, not any other case studies relating to it | India |
| Grover, et al., 2014 [15] | Double case study, longitudinal study | n = 2
1) 65 year old male, no family history of mental illness, smoked cigarettes for over 30 years, suicidal and self harming behaviors before admittance to clinic. 2) 62 year old female, bipolar affective disorder for 35 years, symptoms of psychomotor retardation, depressed mood | 1) About 2 months
2) About 2 months | 1) HDRS (Hamilton depression rating scale) Brain MRI Thyroid function test bilateral modified electro-convulsive treatment (ECT) Thiopentone Succinylcholine Escitalopram Olanzapine Blood tests
2) Brain MRI Blood tests Intravenous lorazepam bilateral modified ECT Thiopentone Succinlycholine BFCR scale Mood stabilizers Olanzapine Fluoxetine | 1) Poor social skills Depressed mood Anhedonia Insomnia Decreased appetite Nihilism Hopelessness Feelings of sin and guilt Delusions of catastrophe, poverty, and persecution Believed he had an illness he could spread that caused cancer, reason for suicidal intent 2) Poor social skills Anxiety Depressed mood Decreased appetite Forgetfulness Psychomotor retardation Delusions of persecution and misidentification | 1) Received 9 ECT treatments in total, all of his symptoms resolved completely in a matter of 7 weeks, and HSDR scale revealed score of 1 compared to initial score of 34
2) Received 8 ECT treatments and all of her depressive, catatonic, and delusional symptoms melted away during this period. Her BFCR scale (for catatonia) decreased from initially 14 to 0 by the end | Both are case reports, so they cannot be generalized to the public
The first report (male) smoked for over 30 years which may have induced symptoms
The second report (female) already had bipolar affective disorder, which may not be associated with Cotard’s syndrome very often | India |