Log IL-10 (pg/ml)

Intent-to-treat analysis

Time

−0.12

0.04

−2.87

0.005

Main effect of group

0.11

0.16

0.66

0.514

Group × time interaction

0.13

0.06

2.11

0.037

Per-protocol analysis

Time

−0.11

0.05

−2.33

0.021

Main effect of group

0.09

0.19

0.47

0.642

Group × time interaction

0.12

0.06

1.93

0.056

STRESS HORMONES

Log Cortisol (mg/L creatinine)

Intent-to-treat analysis

Time

−0.03

0.02

−1.34

0.181

Main effect of group

0.08

0.07

1.18

0.241

Group × time interaction

−0.04

0.03

−1.17

0.245

Per-protocol analysis

Time

−0.01

0.03

−0.53

0.598

Main effect of group

0.11

0.08

1.36

0.175

Group × time interaction

−0.05

0.04

−1.38

0.170

Log Epinephrine (mg/L creatinine)

Intent-to-treat analysis

Time

−0.24

0.05

−4.86

<0.0001

Main effect of group

−0.19

0.13

−1.43

0.156

Group × time interaction

0.13

0.07

1.88

0.063

Per-protocol analysis

Time

−0.25

0.05

−4.51

<0.0001

Main effect of group

−0.15

0.15

−0.98

0.328

Group × time interaction

0.11

0.08

1.52

0.130

Log Norepinephrine (mg/L creatinine)

Intent-to-treat analysis

Time

−0.04

0.03

−1.29

0.200

Main effect of group

−0.06

0.08

−0.76

0.447

Group × time interaction

0.05

0.04

1.15

0.253

Per-protocol analysis

Time

−0.04

0.03

−1.34

0.184

Main effect of group

−0.07

0.09

−0.78

0.438

Group × time interaction

0.05

0.04

1.04

0.301