| IL-10 (pg/ml) |
|||||
| Intention-to-treat analysis |
|||||
| Baseline (63 vs. 59) |
9.43 (8.85) |
9.09 (12.56) |
0.34 (−3.59 to 4.26) |
0.101 |
|
| 12-week (43 vs. 42) |
8.05 (9.13) |
5.74 (8.10) |
2.31 (−1.41 to 6.04) |
0.016 |
|
| 24-week (28 vs. 27) |
6.23 (5.34) |
4.91 (8.62) |
1.32 (−2.59 to 5.24) |
0.012 |
|
| Per-protocol analysis |
|||||
| Baseline (45 vs. 43) |
8.71 (8.73) |
7.70 (11.18) |
1.01 (−3.23 to 5.25) |
0.209 |
|
| 12-week (40 vs. 38) |
8.12 (9.42) |
6.13 (8.41) |
1.99 (−2.05 to 6.03) |
0.038 |
|
| 24-week (26 vs. 24) |
6.16 (5.49) |
5.29 (9.09) |
0.87 (−3.47 to 5.22) |
0.023 |
|
| STRESS HORMONES |
|||||
| Cortisol (mg/L creatinine) |
|||||
| Intention-to-treat analysis |
|||||
| Baseline (62 vs. 62) |
35.50 (19.56) |
32.70 (17.45) |
2.80 (−3.79 to 9.39) |
0.379 |
|
| 12 weeks (46 vs. 42) |
31.15 (19.63) |
30.56 (18.42) |
0.59 (−7.50 to 8.68) |
0.937 |
|
| 24 weeks (28 vs. 27) |
23.19 (9.09) |
28.60 (27.36) |
−5.41 (−16.70 to 5.88) |
0.959 |
|
| Per-protocol analysis |
|||||
| Baseline (43 vs. 46) |
35.90 (20.62) |
31.43 (17.07) |
4.47 (−3.49 to 12.42) |
0.293 |
|
| 12 weeks (44 vs. 38) |
30.41 (19.07) |
31.24 (18.87) |
−0.83 (−9.19 to 7.54) |
0.821 |
|
| 24 weeks (26 vs. 23) |
23.99 ( 8.94) |
30.66 (29.16) |
−6.67 (−19.68 to 6.35) |
0.986 |
|
| Epinephrine (mg/L creatinine) |
|||||
| Intention-to-treat analysis |
|||||
| Baseline (62 vs. 63) |
12.22 (20.95) |
10.29 (17.57) |
1.93 (−4.89 to 8.75) |
0.576 |
|
| 12 weeks (44 vs. 43) |
5.73 (5.55) |
5.28 (4.22) |
0.45 (−1.65 to 2.56) |
0.779 |
|
| 24 weeks (30 vs. 27) |
5.55 (4.49) |
3.67 (3.15) |
1.88 (−0.20 to 3.96) |
0.067 |
|
| Per-protocol analysis |
|||||
| Baseline (46 vs. 46) |
12.58 (22.24) |
10.86 (19.92) |
1.72 (−7.03 to 10.46) |
0.87 |
|
| 12 weeks (42 vs. 39) |
5.75 (5.66) |
5.13 (4.06) |
0.63 (−1.55 to 2.79) |
0.273 |
|
| 24 weeks (28 vs. 23) |
5.35 (4.23) |
3.90 (3.17) |
1.45 (−0.69 to 3.60) |
0.098 |
|
| Norepinephrine (mg/L creatinine) |
|
||||
| Intention-to-treat analysis |
|||||
| Baseline (61 vs. 62) |
52.20 (42.08) |
50.08 (28.79) |
2.12 (−10.79 to 15.03) |
0.85 |
|
| 12 weeks (46 vs. 41) |
60.85 (44.05) |
52.01 (35.07) |
8.83 (−8.28 to 25.95) |
0.748 |
|
| 24 weeks (30 vs. 27) |
52.04 (35.50) |
43.87 (34.52) |
8.17 (−10.46 to 26.80) |
0.198 |
|
| Per-protocol analysis |
|||||
| Baseline (44 vs. 45) |
56.44 (47.59) |
53.29 (31.47) |
3.15 (−13.93 to 20.23) |
0.715 |
|
| 12 weeks (44 vs. 37) |
61.49 (44.64) |
51.31 (32.35) |
10.18 (−7.36 to 27.73) |
0.76 |
|
| 24 weeks (28 vs. 23) |
53.93 (35.94) |
45.11 (35.42) |
8.81 (−11.38 to 29.01) |
0.197 |
|