Measures | Maternal Treatment | Trt × Age P-value | |
Control | Probiotics | ||
Plasma Cortisol, ng/mL |
|
| 0.512 |
7 days old | 44.2 ± 4.4 | 42.6 ± 4.4 |
|
14 days old | 37.9 ± 4.5 | 45.8 ± 4.4 |
|
21 days old | 43.9 ± 4.4 | 50.0 ± 4.4 |
|
28 days old | 24.4 ± 4.4 | 30.3 ± 4.4 |
|
35 days old | 25.6 ± 4.4 | 24.0 ± 4.4 |
|
White Blood Cell (WBC), 107/10 mL |
|
| 0.702 |
7 days old | 6.28 ± 0.54 | 6.02 ± 0.54 |
|
14 days old | 3.40 ± 0.54 | 3.25 ± 0.54 |
|
21 days old | 1.97 ± 0.54 | 2.28 ± 0.54 |
|
28 days old | 2.36 ± 0.54 | 2.14 ± 0.54 |
|
35 days old | 3.43 ± 0.54 | 3.59 ± 0.54 |
|
Neutrophils, % |
|
| 0.146 |
7 days old | 53.6 ± 2.2 | 44.1 ± 2.3 |
|
14 days old | 37.6 ± 2.3 | 32.5 ± 2.2 |
|
21 days old | 32.5 ± 2.2 | 32.3 ± 2.2 |
|
28 days old | 36.6 ± 2.2 | 34.1 ± 2.2 |
|
35 days old | 49.2 ± 2.2 | 41.4 ± 2.2 |
|
Lymphocytes, % |
|
| 0.085 |
7 days old | 44.0 ± 2.2x | 53.3 ± 2.3y |
|
14 days old | 60.2 ± 2.3 | 64.6 ± 2.3 |
|
21 days old | 66.2 ± 2.2 | 65.3 ± 2.3 |
|
28 days old | 59.5 ± 2.2 | 70.0 ± 2.3 |
|
35 days old | 48.2 ± 2.2x | 55.9 ± 2.3y |
|
Monocytes, % |
|
| 0.146 |
7 days old | 2.46 ± 0.51 | 2.23 ± 0.52 |
|
14 days old | 1.92 ± 0.51 | 1.16 ± 0.51 |
|
21 days old | 1.66 ± 0.51 | 2.06 ± 0.51 |
|
28 days old | 3.01 ± 0.51 | 3.85 ± 0.51 |
|
35 days old | 1.68 ± 0.51 | 1.83 ± 0.51 |
|
Eosinophils, % |
|
| 0.262 |
7 days old | 0.27 ± 0.15 | 0.39 ± 0.16 |
|
14 days old | 0.47 ± 0.16 | 0.52 ± 0.15 |
|
21 days old | 0.41 ± 0.15 | 0.36 ± 0.15 |
|
28 days old | 0.53 ± 0.15 | 1.05 ± 0.15 |
|
35 days old | 0.96 ± 0.15 | 0.91 ± 0.15 |
|
Neutrophil-to-Lymphocyte Ratio |
|
| 0.001 |
7 days old | 1.62 ± 0.11a | 0.96 ± 0.11b |
|
14 days old | 0.70 ± 0.11 | 0.60 ± 0.11 |
|
21 days old | 0.54 ± 0.11 | 0.60 ± 0.11 |
|
28 days old | 0.69 ± 0.11 | 0.63 ± 0.11 |
|
35 days old | 1.20 ± 0.11a | 0.82 ± 0.11b |
|
Chemotaxis-C5a, no./5 fields |
|
| 0.227 |
7 days old | 26.9 ± 10.1 | 65.0 ± 12.4 |
|
14 days old | 39.0 ± 9.8 | 99.9 ± 9.6 |
|
21 days old | 44.2 ± 12.0 | 80.9 ± 11.1 |
|
28 days old | 42.1 ± 11.6 | 67.0 ± 10.6 |
|
35 days old | 24.1 ± 15.5 | 89.2 ± 16.9 |
|
Chemotaxis-IL8, no./5 fields |
|
| 0.198 |
7 days old | 27.2 ± 12.7 | 48.6 ± 14.6 |
|
14 days old | 55.0 ± 11.6 | 109.2 ± 11.2 |
|
21 days old | 53.5 ± 12.9 | 62.8 ± 13.4 |
|
28 days old | 35.2 ± 15.7 | 72.3 ± 12.9 |
|
35 days old | 44.6 ± 19.0 | 97.3 ± 22.0 |
|
Neutrophil phagocytosis, % |
|
| 0.063 |
7 days old | 67.4 ± 2.2 | 67.6 ± 2.2 |
|
14 days old | 63.4 ± 2.2 | 60.5 ± 2.2 |
|
21 days old | 56.1 ± 2.2x | 62.6 ± 2.2y |
|
28 days old | 60.5 ± 2.2 | 62.5 ± 2.2 |
|
35 days old | 66.2 ± 2.2 | 68.6 ± 2.2 |
|
Natural killer cell cytotoxicity, % |
|
| <0.0001 |
7 days old | 71.2 ± 4.1 | 69.9 ± 3.9 |
|
14 days old | 63.7 ± 6.3a | 112.9 ± 5.4b |
|
21 days old | 77.5 ± 4.6 | 69.1 ± 4.7 |
|
28 days old | 60.7 ± 4.4 | 52.9 ± 4.4 |
|
35 days old | 57.1 ± 3.7 | 64.5 ± 3.7 |
|
Concanavalin-A proliferation |
|
| 0.026 |
7 days old | 2.25 ± 0.26 | 1.85 ± 0.29 |
|
14 days old | 1.95 ± 0.26 | 2.10 ± 0.29 |
|
21 days old | 2.84 ± 0.24a | 2.07 ± 0.26b |
|
28 days old | 2.12 ± 0.25a | 2.78 ± 0.25b |
|
35 days old | 2.17 ± 0.34 | 2.01 ± 0.33 |
|
Lipopolysaccharide proliferation |
|
| 0.056 |
7 days old | 1.01 ± 0.17a | 1.53 ± 0.18b |
|
14 days old | 1.21 ± 0.19a | 1.51 ± 0.20b |
|
21 days old | 1.30 ± 0.16a | 1.51 ± 0.16b |
|
28 days old | 1.13 ± 0.16 | 1.10 ± 0.16 |
|
35 days old | 1.48 ± 0.11a | 1.89 ± 0.10b |
|
Interleukin-12, pg/mL |
|
| 0.514 |
7 days old | 162.5 ± 25.5 | 154.5 ± 25.7 |
|
14 days old | 257.3 ± 25.6 | 277.0 ± 25.7 |
|
21 days old | 293.1 ± 25.5 | 311.0 ± 25.7 |
|
28 days old | 422.1 ± 25.6 | 411.4 ± 25.7 |
|
35 days old | 315.8 ± 25.5 | 343.5 ± 25.7 |
|