Extracellular matrix

Inflammatory cytokines

Degenerative proteases

Gene

Coll. type II

Aggrecan

Elastin

TNFα

IL-1β

IL-6

MMP-13

ADAMTS4

ADAMTS5

± SEM

1.62 ± 0.33

(+7.5%)

3.23 ± 1.01

(+5.5%)

13.0 ± 4.33

(+6.3%)

0.44 ± 0.15

0.15 ± 0.05

0.55 ± 0.16

0.23 ± 0.05

0.07 ± 0.03

0.01 ± 0.01

p-value

0.034

0.018

0.024

0.003

<0.001

0.003

<0.001

<0.001

<0.001