extended-release Naltrexone (Vivitrol 380 mg)

(n = 1500)

long-acting Nalmefene

(Nalmefene Consta 393.1 mg) (n = 1500)

Alanine aminotransferase increased

150 (10%)

90 (6%)

Aspartate aminotransferase increased

90 (6%)

30 (2%)

Gamma-glutamyltransferase increased

60 (4%)

45 (3%)

Nasopharyngitis

120 (8%)

60 (4%)

Insomnia

120 (8%)

45 (3%)

Influenza

75 (5%)

60 (4%)

Hypertension

60 (4%)

45 (3%)

Injection site pain

120 (8%)

30 (2%)

Toothache

60 (4%)

30 (2%)

Headache

45 (3%)

30 (2%)