Compounds

Antiadipogenesis

MTT

IUPAC Name

R1

R2

R3

R4

R5

R6

IC50 ± SEMa

IC50 ± SEMa

3,3’-((4-Methoxyphenyl)methylene)- bis (6-chloro-4-hydroxy-2H-chromen-2-one) (31)

Cl

H

OCH3

H

H

Cl

>100

NA

3,3’-((4-Methoxyphenyl)methylene)-bis (4-hydroxy-6-methyl-2H-chromen-2-one) (32)

CH3

H

OCH3

H

H

CH3

>100

NA

3,3’-((2-Nitrophenyl)methylene)-bis (4-hydroxy-6-methyl-2H-chromen-2-one) (33)

CH3

H

H

H

NO2

CH3

23.26 ± 0.04

NA

3,3’-((3,4-Dimethoxyphenyl)methylene)-bis (6-chloro-4-hydroxy-2H-chromen-2-one) (34)

Cl

H

OCH3

OCH3

H

Cl

50 ± 0.03

NA

3,3’-((3-Hydroxyphenyl)methylene)-bis (4-hydroxy-6-methyl-2H-chromen-2-one) (35)

CH3

H

H

OH

H

CH3

>100

NA

3,3’-((4-Methylthiophenyl)methylene)-bis (4-hydroxy-6-methyl-2H-chromen-2-one) (36)

CH3

H

SCH3

H

H

CH3

35.53 ± 0.02

NA

3,3’-((3,4,5-Trimethoxyphenyl)methylene)-bis (4-hydroxy-6-methyl-2H-chromen-2-one) (37)

CH3

OCH3

OCH3

OCH3

H

CH3

56.58 ± 0.03

NA

3,3’-((3,4-Dimethoxyphenyl)methylene)-bis (4-hydroxy-6-methyl-2H-chromen-2-one) (38)

CH3

H

OCH3

OCH3

H

CH3

>100

NA