Compounds |
|
|
|
|
| Antiadipogenesis | MTT |
IUPAC Name | R1 | R2 | R3 | R4 | R5 | IC50 ± SEMa | IC50 ± SEMa |
7-Hydroxy-8-methyl-2H-chromen-2- one (8) | CH3 | OH | H | H | H | 48.59 ± 0.03 | NA¥ |
3-Acetyl-8-methoxy-2H-chromen-2-one (9) | OCH3 | H | H | H | COCH3 | 39.54 ± 0.03 | NA¥ |
Ethyl-6,8-dichloro-2-oxo-2H-chromen- 3-carboxylate (10) | Cl | H | Cl | H | COOC2H5 | 37.79 ± 0.03 | NA¥ |
7-Hydroxy-4-methyl-2H-chromen-2-one (11) | H | OH | H | CH3 | H | 26.46 ± 0.03 | NA¥ |
7-Ethoxy-4-methyl-2H-chromen-2-one (12) | H | OC2H5 | H | CH3 | H | 8.0 ± 0.03 | NA¥ |
3-Acetyl-2H-chromen-2-one (13) | H | H | H | H | COCH3 | 62.12 ± 0. 3 | NA¥ |
2-Oxo-2H-chromen-3-carboxamide (14) | H | H | H | H | CONH2 | 29.61 ± 0.015 | NA¥ |
6-Bromo-2-oxo-2H-chromen-3- carboxamide (15) | H | H | Br | H | CONH2 | 53.15 ± 0.03 | NA¥ |
8-Methoxy-2-oxo-2H-chromen-3- carboxamide (16) | OCH3 | H | H | H | CONH2 | 92.10 ± 0.03 | NA¥ |
8-Ethoxy-2-oxo-2H-chromen-3- carboxamide (17) | OC2H5 | H | H | H | CONH2 | >100 | >30 |
8-Ethoxy-3(4-nitrophenyl)-2H- chromen-2-one (18) | OC2H5 | H | H | H | Ph-NO2 | >100 | >30 |
Ethyl-8-methoxy-2-oxo-2H-chromen-3- carboxylate (19) | OCH3 | H | H | H | COOC2H5 | >100 | NA¥ |
3-Acetyl-8-ethoxy-2-oxo-2H-chromen-2 -one(20) | OC2H5 | H | H | H | COCH3 | 50.0 ± 0.01 | NA¥ |
Ethyl-8-ethoxy-2-oxo-2H-chromen-3- carboxylate (21) | OC2H5 | H | H | H | COOC2H5 | 44.38 ± 0.04 | NA¥ |
6-Methoxy-2-oxo-2H-chromen-3- carboxamide (22) | H | H | OCH3 | H | CONH2 | 62.87 ± 0.02 | NA¥ |
6-Methoxy-3(4-nitrophenyl)-2H- chromen-2-one (23) | H | H | OCH3 | H | Ph-NO2 | >100 | >30 |
3-Acetyl-6-methoxy-2H-chromen-2-one (24) | H | H | OCH3 | H | COCH3 | 46.32 ± 0.02 | NA¥ |