Compounds

Antiadipogenesis

MTT

IUPAC Name

R₁

R₂

R₃

R₄

R₅

IC₅₀ ± SEM^a

IC₅₀ ± SEM^a

4-Hydroxy-6-methyl-2H-chromen-2-one (1)

H

H

CH₃

OH

H

40.23 ± 0.02

NA^¥

3-Hydroxy-2H-chromen-2-one (2)

H

H

H

H

OH

>100

NA^¥

6-Methyl-2H-chromen-2-one (3)

H

H

CH₃

H

H

>100

NA^¥

7-Methoxy-2H-chromen-2-one (4)

H

OCH₃

H

H

H

>100

NA^¥

7-Hydroxy-4,8-dimethyl-2H-chromen-

2-one (5)

CH₃

OH

H

CH₃

H

23.74 ± 0.03

NA^¥

3-Chloro-7,8-dihydroxy-4-methyl-2H- chromen-2-one (6)

OH

OH

H

CH₃

Cl

62.29 ± 0.03

cytotoxic

7,8-Dihydroxy-4-methyl-2H-chromen-

2-one (7)

OH

OH

H

CH₃

H

13.63 ± 0.02

NA^¥