Parameter

Healthy Control

Symptomatic Short Stature (Children)

Growth Hormone Therapy

Untreated

Mean ± SD

Mean ± SD

P-value

N = 49

N = 19

N = 33

Age [years]

6.6 ± 1.9

6.9 ± 1.8

5.8 ± 2.4

n.s.

female/male

10/9

16/17

n.s.

GHD/SGA

11/8

9/30

n.s.

ADHD

3

4

n.s.

Birth weight [g]

2281 ± 845

2437 ± 1069

n.s.

Height [cm]

113.3 ± 13.9

103.2 ± 14.6*

0.014

Height SDS

−1.9 ± 1.0

−2.5 ± 0.8*

0.0295

BMI [kg/m²]

14.6 ± 1.3

14.8 ± 1.4

n.s.

BMI Percentile [%]

27 ± 22

27 ± 23

n.s.

NT-Pro-BNP

[0.0 - 85.0 pg/ml]

84 ± 72

169 ± 123*

0.026

IgF 1 [57 - 305 µg/ml]

before treatment

55.5 ± 31.9

n.s.

IgFBP 3 [2100 - 5600 µg/ml]

before treatment

2348 ± 793

n.s.

IgF 1 [57 - 305 µg/ml]

191 ± 104

87 ± 67***

0.0005

IgFBP 3 [2100 - 5600 µg/ml]

3927 ± 983

2922 ± 1050**

0.0057