Glomeruli

Light microscopy:

Enlarged glomeruli

normal glomerular cellularity

increased number of capillary loops

diffusely thickened capillary walls

double contours of glomerular basement membrane

cellular interposition between the glomerular basement

membrane and endothelial cells central mesangiolysis

Immunofluorescence:

Negative (no immune complex deposites)

Electron microscopy:

Lucent flocculent material between the endothelial cells of glomerular capillary and the glomerularbasement membrane

Tubules

Atrophied

Thyroidization

Interstitium

Fibrosis

Intrarenal

Vessels

Grade 1:

Endothelial swelling

mild fibrous arterial intimal thickening

and/or mild patchy arteriolar hyalinosis

Grade 2:

Moderate fibrous arterial intimal thickening

or moderate arteriolar hyalinosis

Grade 3:

Severe occlusive intimal thickening, thrombosis