Stratification

No. of studies

Homozygote Model

(CC vs. TT)

Heterozygote Model

(CT vs. TT)

Dominant Model

(CC + CT vs. TT)

Recessive Model

(CC vs. CT + TT)

Allelic Model

(C vs. T)

OR (95%CI)

P

PQ

OR (95%CI)

P

PQ

OR (95%CI)

P

PQ

OR (95%CI)

P

PQ

OR (95%CI)

P

PQ

Total

34

1.317 (1.119 - 1.549)

0.001

0.000

1.163 (1.057 - 1.279)

0.002

0.000

1.219 (1.095 - 1.357)

0.000

0.000

1.164 (1.013 - 1.337)

0.032

0.000

1.139 (1.047 - 1.240)

0.003

0.000

Cancer Type

CRC

6

1.325 (1.102 - 1.594)

0.003

0.108

1.124 (0.959 - 1.318)

0.147

0.227

1.193 (1.027 - 1.386)

0.021

0.165

1.143 (0.929 - 1.405)

0.206

0.082

1.098 (0.959 - 1.259)

0.177

0.061

ESCC

4

1.213 (0.777 - 1.894)

0.395

0.000

1.279 (0.916 - 1.785)

0.148

0.000

1.256 (0.897 - 1.760)

0.185

0.000

1.017 (0.776 - 1.332)

0.903

0.005

1.080 (0.901 - 1.296)

0.405

0.001

GBC

1

1.039 (0.511 - 2.112)

0.916

-

1.504 (0.724 - 3.123)

0.274

-

1.204 (0.603 - 2.405)

0.598

-

0.741 (0.512 - 1.071)

0.111

-

0.854 (0.636 - 1.147)

0.293

-

GC

6

1.893 (0.978 - 3.663)

0.058

0.000

1.189 (1.017 - 1.389)

0.030

0.171

1.475 (1.007 - 2.162)

0.046

0.000

1.595 (0.851 - 2.987)

0.145

0.000

1.401 (0.942 - 2.083)

0.096

0.000

HCC

11

1.302 (1.019 - 1.663)

0.035

0.000

1.129 (0.940 - 1.355)

0.194

0.002

1.182 (0.977 - 1.431)

0.085

0.000

1.191 (0.997 - 1.422)

0.054

0.002

1.130 (1.004 - 1.272)

0.043

0.000

OSCC

4

1.178 (0.658 - 2.109)

0.582

0.001

1.057 (0.720 - 1.552)

0.778

0.021

1.154 (0.825 - 1.615)

0.403

0.029

1.090 (0.660 - 1.800)

0.735

0.000

1.116 (0.861 - 1.447)

0.406

0.002

PSCC

2

1.331 (0.493 - 3.598)

0.572

0.011

1.352 (0.789 - 2.316)

0.273

0.134

1.364 (0.658 - 2.826)

0.404

0.044

0.995 (0.690 - 1.679)

0.986

0.021

1.086 (0.723 - 1.631)

0.693

0.012

Ethnicity

Asian

25

1.253 (1.081 - 1.451)

0.003

0.000

1.140 (1.032 - 1.260)

0.010

0.001

1.179 (1.067 - 1.304)

0.001

0.000

1.127 (0.999 - 1.271)

0.052

0.000

1.109 (1.035 - 1.188)

0.003

0.000

Caucasian

9

1.544 (0.885 - 2.693)

0.126

0.000

1.275 (0.969 - 1.679)

0.083

0.006

1.400 (0.957 - 2.049)

0.083

0.000

1.269 (0.827 - 1.946)

0.276

0.000

1.236 (0.912 - 1.674)

0.172

0.000

Source of Control

HB

25

1.232 (1.026 - 1.478)

0.025

0.000

1.028 (1.017 - 1.201)

0.018

0.056

1.150 (1.033 - 1.280)

0.011

0.000

1.143 (0.966 - 1.351)

0.119

0.000

1.112 (1.007 - 1.228)

0.036

0.000

PB

9

1.630 (1.148 - 2.314)

0.006

0.000

1.361 (0.992 - 1.868)

0.056

0.000

1.480 (1.104 - 1.983)

0.009

0.000

1.219 (0.966 - 1.538)

0.095

0.001

1.225 (1.049 - 1.431)

0.010

0.001