Stratification | No. of studies | Homozygote Model (CC vs. TT) | Heterozygote Model (CT vs. TT) | Dominant Model (CC + CT vs. TT) | Recessive Model (CC vs. CT + TT) | Allelic Model (C vs. T) | ||||||||||
OR (95%CI) | P | PQ | OR (95%CI) | P | PQ | OR (95%CI) | P | PQ | OR (95%CI) | P | PQ | OR (95%CI) | P | PQ | ||
Total | 34 | 1.317 (1.119 - 1.549) | 0.001 | 0.000 | 1.163 (1.057 - 1.279) | 0.002 | 0.000 | 1.219 (1.095 - 1.357) | 0.000 | 0.000 | 1.164 (1.013 - 1.337) | 0.032 | 0.000 | 1.139 (1.047 - 1.240) | 0.003 | 0.000 |
Cancer Type |
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CRC | 6 | 1.325 (1.102 - 1.594) | 0.003 | 0.108 | 1.124 (0.959 - 1.318) | 0.147 | 0.227 | 1.193 (1.027 - 1.386) | 0.021 | 0.165 | 1.143 (0.929 - 1.405) | 0.206 | 0.082 | 1.098 (0.959 - 1.259) | 0.177 | 0.061 |
ESCC | 4 | 1.213 (0.777 - 1.894) | 0.395 | 0.000 | 1.279 (0.916 - 1.785) | 0.148 | 0.000 | 1.256 (0.897 - 1.760) | 0.185 | 0.000 | 1.017 (0.776 - 1.332) | 0.903 | 0.005 | 1.080 (0.901 - 1.296) | 0.405 | 0.001 |
GBC | 1 | 1.039 (0.511 - 2.112) | 0.916 | - | 1.504 (0.724 - 3.123) | 0.274 | - | 1.204 (0.603 - 2.405) | 0.598 | - | 0.741 (0.512 - 1.071) | 0.111 | - | 0.854 (0.636 - 1.147) | 0.293 | - |
GC | 6 | 1.893 (0.978 - 3.663) | 0.058 | 0.000 | 1.189 (1.017 - 1.389) | 0.030 | 0.171 | 1.475 (1.007 - 2.162) | 0.046 | 0.000 | 1.595 (0.851 - 2.987) | 0.145 | 0.000 | 1.401 (0.942 - 2.083) | 0.096 | 0.000 |
HCC | 11 | 1.302 (1.019 - 1.663) | 0.035 | 0.000 | 1.129 (0.940 - 1.355) | 0.194 | 0.002 | 1.182 (0.977 - 1.431) | 0.085 | 0.000 | 1.191 (0.997 - 1.422) | 0.054 | 0.002 | 1.130 (1.004 - 1.272) | 0.043 | 0.000 |
OSCC | 4 | 1.178 (0.658 - 2.109) | 0.582 | 0.001 | 1.057 (0.720 - 1.552) | 0.778 | 0.021 | 1.154 (0.825 - 1.615) | 0.403 | 0.029 | 1.090 (0.660 - 1.800) | 0.735 | 0.000 | 1.116 (0.861 - 1.447) | 0.406 | 0.002 |
PSCC | 2 | 1.331 (0.493 - 3.598) | 0.572 | 0.011 | 1.352 (0.789 - 2.316) | 0.273 | 0.134 | 1.364 (0.658 - 2.826) | 0.404 | 0.044 | 0.995 (0.690 - 1.679) | 0.986 | 0.021 | 1.086 (0.723 - 1.631) | 0.693 | 0.012 |
Ethnicity |
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Asian | 25 | 1.253 (1.081 - 1.451) | 0.003 | 0.000 | 1.140 (1.032 - 1.260) | 0.010 | 0.001 | 1.179 (1.067 - 1.304) | 0.001 | 0.000 | 1.127 (0.999 - 1.271) | 0.052 | 0.000 | 1.109 (1.035 - 1.188) | 0.003 | 0.000 |
Caucasian | 9 | 1.544 (0.885 - 2.693) | 0.126 | 0.000 | 1.275 (0.969 - 1.679) | 0.083 | 0.006 | 1.400 (0.957 - 2.049) | 0.083 | 0.000 | 1.269 (0.827 - 1.946) | 0.276 | 0.000 | 1.236 (0.912 - 1.674) | 0.172 | 0.000 |
Source of Control |
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HB | 25 | 1.232 (1.026 - 1.478) | 0.025 | 0.000 | 1.028 (1.017 - 1.201) | 0.018 | 0.056 | 1.150 (1.033 - 1.280) | 0.011 | 0.000 | 1.143 (0.966 - 1.351) | 0.119 | 0.000 | 1.112 (1.007 - 1.228) | 0.036 | 0.000 |
PB | 9 | 1.630 (1.148 - 2.314) | 0.006 | 0.000 | 1.361 (0.992 - 1.868) | 0.056 | 0.000 | 1.480 (1.104 - 1.983) | 0.009 | 0.000 | 1.219 (0.966 - 1.538) | 0.095 | 0.001 | 1.225 (1.049 - 1.431) | 0.010 | 0.001 |