Type II:

・ Factor V Leiden (a mutation in the F5 gene at position 1691)

・ Prothrombin G20210A, a mutation in Prothrombin (at position 20210 in the 3’ untranslated region of the gene)

Type I:

・ Antithrombin III deficiency

・ Protein C deficiency

・ Protein S deficiency

・ Factor XIII mutation

・ Familial dysfibrinogenemia

・ Antiphospholipid syndrome

・ Paroxysmal nocturnal hemoglobinuria (PNH)

・ Heparin-induced thrombocytopenia (HIT)

・ Sickle cell anemia

・ Myeloproliferative disorders

・ Cancer, particularly when metastatic

・ Nephrotic syndrome

・ Inflammatory bowel disease (ulcerative colitis and Crohn's disease)

・ Pregnancy

・ Hormone replacement therapy

・ Morbid obese