Moderate renal failure (CrCl 30 - 50 ml/min.)

1

Male Sex

1

Age 40 - 84 years

1.5

Active Cancer

2

Rheumatic disease

2

Central venous catheters

2

Admissions in Intensive Care

2.5

Severe Renal Failure (CrCl < 30 ml/min.)

2.5

Liver insufficiency (INR > 1.5)

2.5

Age ≥ 85

3.5

Thrombocytopenia (<50 × 10⁹ cell/L)

4

Recent (3 months) bleeding

4

Active gastro-intestinal ulcer

High bleeding risk when total score ≥ 7