| Risk group | Recommended prophylaxis |
| Low VTE risk (Padua < 4) | Recommend against the use of pharmacologic or mechanical prophylaxis (Grade 1B) |
| Low VTE risk (Paudua < 4) with high bleed risk | Recommend against anticoagulant thromboprophylaxis (Grade 1B) |
| High VTE risk (Padua ≥ 4) | Thromboprophylaxis with LMWH (Grade 1B), LDUH BID or TID (Grade 1B), or fondaparinux (Grade 1B). |
| High VTE risk (Padua ≥ 4) with high bleed risk | Mechanical thromboprophylaxis with graduated compression stockings (GCS) (Grade 2C) or intermittent pneumatic compression (IPC) (Grade 2C). When bleeding risk decreases suggest pharmacologic thromboprophylaxis is substituted for mechanical thromboprophylaxis (Grade 2B). |
| Extended duration of thromboprophylaxis | Recommend against extending the duration of thromboprophylaxis beyond the period of patient immobilization or acute hospital stay. |