Study 1

Study 2

Study 3

Study 4

Study 5

Trial Effect

(SD)

−0.72387

(0.01021)

1.20619

(0.00934)

−0.54688

(0.00993)

−3.01061

(0.0117)

0.55283

(0.00926)

95% CI

(−0.74, −0.70)

(1.18, 1.22)

(−0.56, −0.52)

(−3.03, −0.98)

(0.53, 0.57)

Study 6

Study 7

Study 8

Study 9

Study 10

Trial Effect

−0.85773

−1.69947

−0.34480

−0.65231

−1.29308

(SD)

95% CI

0.01206)

(0.88, −0.83)

(0.01264)

(−1.72, −1.67)

(0.00735)

(−0.35, −0.33)

(0.00770)

(−0.66, −0.63)

(0.01087)

(−1.31, −1.27)

Study 11

Study 12

Study 13

Study 14

Study 15

Trial Effect

(SD)

2.18147

(0.01231)

1.68130

(0.00636)

1.17724

(0.00811)

0.68567

(0.00869)

−0.14132

(0.01102)

95% CI

(−2.20, −2.15)

(1.66, 1.69)

(1.16, 1.19)

(0.66, 0.70)

(−0.16, −0.11)

Study 16

Study 18

Study 18

Study 19

Study 20

Trial Effect

(SD)

−1.53114

(0.01214)

−0.57320

(0.00941)

−0.33486

(0.00661)

−4.24972

(0.01367)

−1.05748

(0.01199)

95% CI

(−1.55, −1.50)

(−0.59, −0.55)

(−0.34, −0.32)

(−4.27, −4.22)

(−1.08, −1.03)

Study 21

Study 22

Study 23

Study 24

Study 25

Trial Effect

(SD)

−3.01727

(0.01184)

−0.11773

(0.00977)

−2.23388

(0.01252)

0.24853

(0.00802)

0.04007

(0.00987)

95% CI

(−3.04, −2.99)

(−0.13, −0.09)

(−2.25, −2.20)

(0.23, 0.26)

(0.02, 0.05)

Study 26

Study 27

Trial Effect

(SD)

−0.37573

(0.01277)

−0.76995

(0.01098)

95% CI

(−0.40, −0.35)

(−0.79, −0.74)