| PASCAL® | NAVILAS® | SDM | SRT | 2RT® | |
| Laser devices | 532-nm Nd-YAG/514-nm argon laser | 577-nm Yellow laser | 810-nm diode laser | 527-nm Nd-YLF/532-nm Nd-YAG laser | 532-nm Nd-YAG laser |
| Pulse duration | 10 - 1000 msec | 10 - 1000 msec | 100 - 300 μsec | 1.7 μsec/15 - 60 msec | 3 nsec |
| Indications | PDR/DME/RVO | PDR/DME/RVO | CSCR/DME | CSCR/DME | Early AMD |
| Advantages | Shortened treatment time/Increased safety | Eye-tracking/Better accuracy | Minimized collateral tissue damage | Selectively damage RPE cells | Confine laser energy to RPE cells |
| Limitations | Uncontrolled eye movements | No stereoscopic view/Unavailability of ICG angiography | Long treatment time/Treatment protocols not well-established | Lack of non-invasive methods to detect treatment effects | No visible reaction on RPE/Impossible to determine the treated area |