o Pruritus

28 (2.9%)

4 (3.2%)

o Psychiatric disturbance

12 (1.3%)

6 (4.8%)

o Peripheral neuropathy

8 (0.8%)

8 (6.4%)

o Mild anemia (Hb ≥ 8 g/l)

6 (0.6%)

4 (3.2%)

o Facial paralysis

1 (0.6%)

0

o Sexual disturbance

1 (0.1%)

o Grade 3 - 4 (n, %)

93 (9.8%)

9 (7.2%)

o Severe hearing loss

83 (8.7%)

2 (1.7%)

o Retrobulbar neuritis

11 (1.1%)

2 (1.7%)

o Psychiatric troubles

1 (0.1%)

2 (1.6%)

o Severe anemia

1 (0.1%)

3 (2.4%)

o Hepatitis

1 (0.1%)

0

o Epidermolysis

1 (0.1%)

0