Inclusion criteria | Exclusion criteria |
1) Patients who met the criteria of TB diagnosis and treatment guidelines made by TB Branch of Chinese Medical Association [39] ; | 1) Patients with severe liver and kidney disease history; |
2) Mtb strains from them were sensitive to INH + RIF + EMB according to pre-treatment drug susceptibility testing; | 2) Mental illness, gout and diabetes history; |
3) Alanine aminotransferase (ALT) ≤ 3 times upper limit of normal (ULN); | 3) HIV antibody positive, long-term use of immunosuppressive agents, severe malnutrition; |
4) Total bilirubin ≤ 2.5 times ULN; | 4) Currently enrolled in or was going to start medications of antiretroviral and/or immunosuppressive agents in next 8 weeks. |
5) Creatinine ≤ 2 times ULN; | 5) Discontinuation of treatment due to serious adverse effects; |
6) Hemoglobin ≥ 7.0 g/dL; | 6) Failure to complete the six-month treatment program; |
7) Platelets ≥ 100,000/mm3; | 7) Pregnancy or breast-feeding; |
8) Non-pregnant; | 8) Weight < 40 kg; |
9) ≤5 days of anti-tuberculosis treatment in last 6 months. | 9) Central nervous system tuberculosis; |
| 10) Pulmonary silicosis. |