Entry | 1a (mmol) | 3 (eq) | NaH (eq) | Solvent | Source energy activation | Time (h) | Yield (%) | ||||
4a | 5 | 6a | 7 | ||||||||
1 | 3.3 | 3 | 1.5 | Toluene | MW | 1 | -a | 55 | - | - | |
2 | 3.3 | 9 | 3 | Toluene | MW | 3 | 60 | - | - | - | |
3 | 16.6 | 9 | 3 | Toluene | MW | 1.5 | 87 | - | - | - | |
4 | 66.6 | 9 | 3 | Toluene | r. t. | 1.6 | 11 | - | 29 | 5 | |
5 | 33.3 | 9 | 3 | Toluene | 55˚Cb | 1 | 87 | - | - | - | |
6 | 33.3 | 9 | 3 | THF | 55˚Cb | 0.25 | 62 | - | - | - |