| Colon cancer | In Vitro | HCT116 LOVO | ↑Apoptosis ↓Viability ↓Growth Emodin induces autophagy to induce apoptosis of colon cancer cells, in which the production of reactive oxygen species is the key | [39] |
| Colon cancer | In Vitro | CACO-2 | ↓Proliferation ↑Apoptosis Emodin has shown effective anticancer effects in Caco-2 human colon cancer cells by inducing apoptosis, cell cycle arrest and inhibiting PI3K/Akt signaling pathway. | [23] |
| Cervical cancer | In Vitro | HeLa | ↑Apoptotic cells ↓Viability Emodin induces degradation and promotes the death of tumor cells through a mechanism that is clearly involved in lysosomal loci. | [21] |
| Cervical cancer | In Vitro | HeLa celIs | ↑Apoptotic ↓Viability Emodin causes cervical cancer cell death by inducing mitotic catastrophes | [41] |
| Ovarian cancer | In Vitro | A2780 SK-OV-3 | ↓Proliferation ↓Migration ↓Invasion ↓EMT Emodin inhibits EMT in EOC cells through ILK/GSK-3β/slug signaling pathway. | [27] |
| Ovarian cancer | In Vitro | A2780 SK-OV-3 | ↓Invasion ↓EMT In Vitro, EMO inhibited epithelial ovarian cancer cell invasion by regulating the GSK-3β/β-catenin /ZEB1 signaling pathway. | [28] |