Cancer

In Vitro/In Vivo

/Ex Vivo

Model/cell

Mechanism/Results

References

Anaplastic thyroid cancer

In Vitro and In Vivo

8505c,

SW1736

↓Proliferation

↓Metastatic ability

↓Angiogenesis and metastasis

Emodin exerts anti-angiogenic and anti-metastatic activities in ATC by affecting TRAF6 mediated pathways.

[25]

Breast cancer

In Vitro

MDA-MB-231

MDA-MB-453

Proliferation ↓Metastasis

Emodin inhibits adipocyte secretion of CCL5, inhibits the EMT of TNBC cells, and inhibits tumor growth and lung and liver metastasis, suggesting that emodin has a new role in the prevention of TNBC metastasis.

[22]

Lung cancer

In Vitro

A549

↓Viability

↓Proliferation

Emodin regulates the cell cycle of non-small cell lung cancer cells through a HAS2-HACD44/RHAMM interaction-dependent signaling pathway.

[33]

Lung cancer

In Vitro and In Vivo

HL-60N1

↑ROS, ↓autophagy, induced apoptosis

Emodin selectively inhibits N2 neutrophils, thereby preventing hypercoagulability and the development of lung cancer.

[34]

lung cancer

In Vitro

A549

H1299

↓Viability

↑Apoptosis

The TRIB3 signal is associated with emodin-induced endoplasmic reticulum stress-mediated apoptosis of lung cancer cells

[19]

lung cancer

In Vitro

A549

↓Proliferation

↓Viability

↓Migration

Emodin inhibits ATP-induced proliferation, migration, and EMT by inhibiting P2Y receptor mediated [Ca2+]I increase and NF-κB signaling in A549 cells.

[32]

Hepatocellular carcinoma

In Vitro

HepG2

↓Viability

↓Proliferation

↓Growth

859 DEGs and 5 HUB genes were identified, which may be regarded as the target of emodin therapy for HCC.

[20]

Hepatocellular carcinoma

In Vitro

Bel-7402

↓Proliferation

↑Apoptosis

↓Viability

Emodin can induce apoptosis of hepatocellular carcinoma cells in SREBP 1-dependent and SREBP 1-independent ways.

[26]

Hepatocellular carcinoma

In Vitro

HepG2

↑Apoptosis

Emodin induces apoptosis by up-regulation of CypD

[37]

Hepatocellular carcinoma

In Vitro

SMMC-7721

↑Apoptosis

↓Proliferation

Emodin may be a potentially effective and safe drug to induce apoptosis in HCC cells

[38]

Colon cancer

In Vitro

HCT116

SW480

SNU-C2ASNU-C5

↓Proliferation

Emodin provides a molecular basis for the treatment of colon cancer by inhibiting FASN-mediated cell growth and apoptosis.

[40]