| Drug | Dose (Administration method) | Effect of statins on intracranial aneurysm | Animals used | Methods for induction of aneurysm | 1st Author | Journal |
| Simvastatin | 25 mg/kg/day | 1) Suppression of enlargement of intracranial aneurysm | male rats | High salt diet | Aoki T | Stroke.2008; 39:1276-1285. |
| (mixed in chow) | 2) Suppression of further enlargement of pre-existing aneurysm | Ligation of left common carotid artery and posterior branches of bilateral renal arteries | ||||
| Pitavastatin | 5 mg/kg/day | 1) Suppression of enlargement of aneurysm | male rats | High salt diet | Aoki T | Neurosurgery. 2009; 64:357-365 |
| (mixed in chow) | 2) Suppression of further enlargement of pre-existing aneurysm | Ligation of left common carotid artery and posterior branches of bilateral renal arteries | ||||
| Pravastatin | 50 or 100 mg/kg/day | Reduction of the ratio of aneurysms in advanced stage | female rats | Drinking water containing 1% NaCl | Kimura N | Brain research. 2010; 1322:144-152 |
| (mixed in chow) | Ligation of right common carotid artery and posterior branches of bilateral renal arteries | |||||
| Bilateral oophorectomy | ||||||
| Pravastatin | 5 mg/kg/day (gavage) | Reduction of the ratio of aneurysm formation | female rats | Drinking water containing 1% NaCl | Tada Y | Stroke.2011; 42:2286-2293 |
| 25 or 50 mg/kg/day (gavage) | Increase of the ratio of aneurysm formation | Ligation of left common carotid artery and bilateral posterior renal arteries | ||||
| Simvastatin | 5 mg/kg/day (gavage) | Increase of the ratio of aneurysm formation | Bilateral oophorectomy |