Variable

HR (95% CI)

p

Grouped Stages

Early

Reference

Advanced

2.03 (1.45 - 2.84)

0.000

Metastatic

1.47 (0.83 - 2.58)

0.186

Age grouped

<46 years

Reference

46 - 54

0.76 (0.48 - 1.22)

0.253

55 - 64

1.02 (0.65 - 1.59)

0.946

≥65 years

1.54 (1.02 - 2.32)

0.039

Localization

UOQ

Reference

LOQ

1.10 (0.67 - 1.81)

0.707

UIQ

1.12 (0.74 - 1.70)

0.590

UIQ

0.80 (0.42 - 1.51)

0.494

Retro areolar

0.61 (0.34 - 1.10)

0.099

Multifocal

2.88 (1.52 - 5.45)

0.001

Multicentric

1.23 (0.82 - 1.85)

0.322

Differentiation

Well

Reference

Moderately

2.21 (1.33 - 3.65)

0.002

Poorly

2.57 (1.53 - 4.33)

0.000

Phenotype

Luminal A

Reference

Luminal B

1.26 (0.73 - 2.19)

0.408

HER2 positive

1.07 (0.66 - 1.73)

0.797

Triple negative

1.72 (1.18 - 2.53)

0.005

Type of surgery

No surgery

Reference

Conservative

0.48 (0.29 - 0.78)

0.003

Radical

0.52 (0.35 - 0.79)

0.002

Metastatic disease

NO metastasis

Reference

Metastasis

4.91 (3.62 - 6.65)

0.000