Adverse outcome

Relative risk (RR)

95% CI for RR

Z

Score*

p-value

Number needed to treat (NNT)

95% CI for NNT

GI upset

0.43

0.33 to 0.56

6.142

<0.0001

2.5

1.98 to 3.4

Vomiting

0.57

0.38 to 0.84

2.812

0.005

6.6

4.0 to 19.9

Constipation

0.61

0.49 to 0.76

4.411

0.0001

3.7

2.6 to 6.3