Visit 2 (2)

Visit 3 (3)

End of study (4)

p value (Overall)

Disappearance of manifestations

<0.001c

None

1 (1.8%)3,4

02

1 (1.8%)2

Slight

6 (10.7%)

4 (7.1%)

4 (7.1%)

Moderate

31 (55.4%)

5 (8.9%)

16 (28.6%)

Great

18 (32.1%)

47 (83.9%)

35 (62.5%)

Skin quality improvement

<0.001c

None

03,4

02

02

Slight

4 (7.1%)

0

2 (3.6%)

Moderate

31 (55.4%)

8 (14.3%)

14 (25%)

Great

21 (37.5%)

48 (85.7%)

40 (71.4%)

Assessment of total improvement

<0.001c

None

03,4

02

1 (1.8%)2

Slight

3 (5.4%)

3 (5.4%)

2 (3.6%)

Moderate

33 (58.9%)

6 (10.7%)

14 (25%)

Great

20 (35.7%)

47 (83.9%)

39 (69.6%)