Baseline (1)

Visit 2 (2)

Visit 3 (3)

End of study (4)

p value (Overall)

Erythema

55 (98.2%)^2,3,4

31 (55.4%)^1,3,4

4 (7.1%)^1,2,4a

16 (28.6%)^1,2,3a

<0.001^b

Scaling

48 (85.7%)^2,3,4

13 (23.2%)^1,3a

1 (1.8%)^1,2a

7 (12.5%)¹

<0.001^b

Infiltration

29 (51.8)^2,3,4

9 (16.1%)^1,3a

1 (1.8%)^1,2a

7 (12.5%)¹

<0.001^b

Excoriations

38 (67.9%)^2,3,4

15 (26.8%)^1,3a

4 (7.1%)^1,2a

12 (21.4%)¹

<0.001^b

Lichenification

43 (76.8%)^2a,3,4

33 (58.9%)^1a,3,4

6 (10.7%)^1,2

14 (25.0%)^1,2

<0.001^b

Xerosis

44 (78.6%)^2,3,4

21 (37.5%)^1,3,4a

0^1,2

8 (14.3%)^1,2a

<0.001^b

Pruritus

46 (82.1%)^2,3,4

12 (21.4%)^1,3a

2 (3.6%)^1,2a

7 (12.5%)¹

<0.001^b