9

Cancer institute August 25, 2011

Fibrillary astrocytoma, Grade 2

Regional hospital MRI June 27, 2011

Contrast-enhancing lesion in right temporo-parieto-occipital area

Partial tumor resection August 19, 2011

Cancer institute November 22, 2011

Astrocytoma, Grade 2/3

Repeat partial tumor resection November 7, 2011

Institute of neurology May 23, 2013

GBM

RT 5400 cGy January 16, 2012 to February 20, 2012

Cancer institute MRI February 2, 2013

Recurrence

Repeat partial tumor resection May 15, 2013

TMZ 5 days (28 day cycle x9) May 2013 to February 2014

Cancer institute MRI January 27, 2014

Recurrence

PCV chemotherapy ×2 March 2014 to May 14, 2014

Cancer institute MRI May 14, 2014

Recurrence

BC. June 19, 2014 PB, sorafenib, pazopanib, everolimus, dasatinib, BVZ

Regional radiology MRI August 28, 2014

PR

IDH1-R132H mutation, CDK4-amplification, TP53 loss (G245S), ATRX-R808 mutation EPHA3 loss (V4121) (tissue)

10

University hospital September 4, 2013

GBM

University hospital MRI August 20, 2013

Enhancing mass in the right occipital lobe

Gross tumor resection August 23, 2013.

Standard RT and TMZ September 20, 2013 to November 20, 2013.

TMZ, 28 day cycle December 2013 to June 30, 2014.

Regional radiology MRI July 18, 2014

Recurrence

BC. July 28, 2014 PB, pazopanib, everolimus, dasatinib, BVZ

Regional radiology MRI September 4, 2014

CR*

HER-2-elevated, EGFR and VEGF-normal (blood), NF1-loss of function rearrangement exxon 31, PIK3CA-H1047L mutation, CDKN2A-loss equivocal (tissue)

11

University hospital January 27, 2014

GBM

University hospital MRI January 7, 2014

Left frontal lobe tumor

Partial tumor resection January 9, 2014.

Standard RT with TMZ February 28, 2014 to April 8, 2014.

TMZ every 28 days May 5, 2014 to August 1, 2014.

Regional radiology August 19, 2014

Recurrence

BC. August 18, 2014 PB, pazopanib, everolimus, dasatinib, BVZ

Regional radiology MRI September 16, 2014

PR**

HER-2, VEGF-elevated, EGFR-normal (blood), NF1 loss-Y2885 fs*5 mutation, NF2 loss-5518 fs*4 mutation, FANCG, GATA2, HSD3B1, IKBKE, NOTCH2 mutations (tissue)