Response groups

Responsive

Partially responsive

Both groups

Interval p-value

Interval p-value

Comparison p-value

Changes in creatinine clearance:

Time 0:

72 (6)

68 (10)

NS

<0.04

NS

Time 3 M:

82 (10)

72 (8)

<0.04

<0.04

NS

Time 12 M:

92 (18)

77 (14)

<0.001

NS

NS

Time 24 M:

92 (12)

76 (16)

<0.001

Final p-value (0 - 24):

<0.04

NS

Changes in protein output:

Time 0:

3730 (890)

4020 (380)

NS

<0.04

NS

Time 3 M:

460 (140)

1805 (110)

<0.001

NS

NS

Time 12 M:

440 (230)

1535 (210)

<0.001

NS

NS

Time 24 M:

380 (290)

1650 (180)

<0.001

Final p-value (0 - 24):

<0.04

NS