Doses

75

150

300

600

1200

Average sample size/% Stop. Trials

Prob. True Toxicity

0.05

0.10

0.25

0.45

0.6

Prob. True Activity

0.20

0.40

0.60

0.8

0.55

BDTM: % allocation

23.8

38.0

33.5

4.6

0.1

N = 23

BDTM: % selection

1.3

37.8

52.4

2.4

0

6.1

BDEM + BDTM: % allocation

30.7

33.5

35.8

0

0

N = 24

BDEM + BDTM: % selection

0.9

25.9

70.7

0

0

2.5