| Part of the plant | Extract | Affected organ | Model | Dose | Key result | Reference |
| Leaves | Ethanolic Extract | Liver | In vivo | 1000 mg/kg | Mild infiltration of inflammatory cells. | [25] |
| In vivo | 2000 mg/kg | Increased infiltration of inflammatory cells. | ||||
| In vivo | 5000 mg/kg | Severe infiltration of inflammatory cells. | ||||
| Leaves | Ethanolic Extract | Kidney | In vivo | 1000 mg/kg | A dose of 1000 mg/kg BW already shows the occurrence of mesangial cell proliferation but has not shown hypertrophy of glomerular tissue. | [25] |
| 2000 mg/kg | The dose of 2000 mg/kg BW already shows hypertrophy of the glomerular tissue. | [25] | ||||
| 5000 mg/kg BW | At doses of 5000 mg/kg BW has increased the proliferation of mesangial cells, Bowman’s capsule, narrowing of tubular lumen due to enlarged cells, and visible tubular damage. |
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| Leaves | Ethanolic Extract | Pancreas | In vivo | 2000 & 5000 mg/kg | In the treatment of doses of 2000 and 5000 mg/kg BW has appeared that the glands around the Langerhans island begun to swell. Cell changes caused by substances that have the cytotoxic effect are the reduction of the Langerhans islands, the reduction of β-cell counts, degranulation, and vacuolization of these cells. | [25] |
| Leaves | Ethanolic Extract | Heart | In vivo | 2000 mg/kg & 5000 mg/kg | A dose of 2000 mg/kg BW has begun to show an abnormal cell nucleus that was necrosis. While at a dose of 5000 mg/kg BW has occurred of necrosis and fatty tissue infiltration. | [25] |
| Leaves | Ethanolic Extract | Lung | In vivo | 1000 mg/kg, 2000 mg/kg & 5000 mg/kg | The dose of 1000 mg/kg BW still appears normal. While the dose of 2000 mg/kg BW has begun thickening of the bronchial epithelium. While the dose of 5000 mg/kg BB occurs of epithelial cells damage. | [25] |