Sex

Dose (mg/kg)

Urinary protein (mg/dl)

Serum urea (mg/dl)

Urinary urea (mg/dl)

Serum creatinine (mg/dl)

Urinary creatinine (mg/dl)

Males

Control

4.61 ± 0.13

46.62 ± 2.54

1249 ± 89.81

78.00 ± 4.00

0.47 ± 0.09

250

5.41 ± 0.12^***

60.81 ± 3.19^***

765.4 ± 5.15^***

60.50 ± 3.41^***

0.42 ± 0.05 ^ns

500

5.10 ± 0.04^***

64.21 ± 3.47^***

845.3 ± 28.27^***

37.50 ± 3.78^***

0.45 ± 0.10 ^ns

1000

5.20 ± 0.03^***

72.44 ± 1.89^***

1045 ± 81.35^***

21.00 ± 3.83^***

0.40 ± 0.00 ^ns

Satellite

5.28 ± 0.09^***

75.00 ± 0.55^***

1488 ± 26.56^***

85.00 ± 3.83^ns

0.42 ± 0.12 ^ns

Females

Control

6.11 ± 0.04

44.48 ± 3.14

1324 ± 88.09

90.75 ± 3.59

1.42 ± 0.17

250

5.25 ± 0.06^***

53.51 ± 4.56^**

1023 ± 23.78^***

64.00 ± 3.26^***

0.42 ± 0.05^***

500

5.25 ± 0.03^***

55.65 ± 0.90^***

1067 ± 51.45^***

32.75 ± 1.50^***

0.52 ± 0.15^***

1000

5.38 ± 0.06^***

56.56 ± 1.69^***

1327 ± 78.29^ns

25.75 ± 1.70^***

1.65 ± 0.10^ns

Satellite

5.11 ± 0.07^***

72.75 ± 3.37^***

1457 ± 38.99^*

88.75 ± 6.70^ns

2.22 ± 0.17^***