Minor criteria

● Predisposition, predisposing heart condition or injection drug use

● Fever, temperature > 38˚C

● Vascular phenomena, major arterial emboli, septic pulmonary infarcts, mycotic aneurysm, intracranial hemorrhage, conjunctival hemorrhages and Janeway’s lesions

● Immunologic phenomena: glomerulonephritis, Osler’s nodes, Roth’s spots and rheumatoid factor

● Microbiological evidence: positive blood culture but does not meet a major criterion as noted above * or serological evidence of active infection with organism consistent with IE

Interpretation

Definite infective endocarditis:

Pathological criteria

● Microorganism: demonstrated by culture or histology in a vegetation or in a vegetation that has embolized, or in a intracardiac abscess or

● Pathologic lesions: vegetation or intracardiac abscess present confirmed by histology showing active endocarditis

Clinical criteria:

● 2 major criteria, or

● 1 major and 3 minor,

● or 5 minor

Possible infective endocarditis

● 1 major and 1 minor, or

● 3 minor

● Rejected

Diagnosis of infective endocarditis is rejected

● Firm alternate diagnosis explaining evidence of infective endocarditis, or

● Resolution of infective endocarditis syndrome, with antibiotic therapy for 4 days or less, or

● No pathologic evidence of infective endocarditis at surgery or autopsy, with antibiotic therapy for 4 days or less