CRP > 100 mg/l or more than 50 mg/l that has doubled in the last 48 hours
Lymphocyte recount < 0.6 × 109
Interleukin-6 (IL-6) > 3 its normal limit
Ferritin > 300 µg/L
DHL > 250 U/L
D dimer > 1 µg/L.